The Revolution Will Be Computed: Fantasy, Apple Computer, and the Ethos of Silicon Valley

My thesis undertakes a rhetorical analysis of the discourse surrounding the development of the personal computer and Apple Computer as a case study in Silicon Valley discourse. The analysis spans twenty years (1964-1984) starting with San Francisco-area computer hobbyist clubs and ending with the release of Macintosh by Apple Computer. Symbolic convergence theory (SCT) and fantasy theme analysis (FTA) provide the primary methodology for my work. Because SCT/FTA developed from small group communication research, they are fitting tools for understanding how small groups of people impassioned about building something new can impact public discourse. I connect SCT/FTA with a materialist approach to rhetoric, as well as affect theory and ethos. This methodological synthesis contributes to a broader understanding of the complex interplay between environments, objects, and symbols. I conclude that the development of the personal computer was supported by particular environments and five primary fantasies. The personal computer is (1) possible (2) revolutionary (3) democratizing (4) necessary and (5) user-friendly

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?

Obesity and non-alcoholic fatty liver disease (NAFLD) are contributing to the global rise in deaths from hepatocellular carcinoma (HCC). The pathogenesis of NAFLD-HCC is not well understood. The severity of hepatic steatosis, steatohepatitis and fibrosis are key pathogenic mechanisms, but animal studies suggest altered immune responses are also involved. Genetic studies have so far highlighted a major role of gene variants promoting fat deposition in the liver (PNPLA3 rs738409; TM6SF2 rs58542926). Here, we have considered single-nucleotide polymorphisms (SNPs) in candidate immunoregulatory genes (MICA rs2596542; CD44 rs187115; PDCD1 rs7421861 and rs10204525), in 594 patients with NAFLD and 391 with NAFLD-HCC, from three European centres. Associations between age, body mass index, diabetes, cirrhosis and SNPs with HCC development were explored. PNPLA3 and TM6SF2 SNPs were associated with both progression to cirrhosis and NAFLD-HCC development, while PDCD1 SNPs were specifically associated with NAFLD-HCC risk, regardless of cirrhosis. PDCD1 rs7421861 was independently associated with NAFLD-HCC development, while PDCD1 rs10204525 acquired significance after adjusting for other risks, being most notable in the smaller numbers of women with NAFLD-HCC. The study highlights the potential impact of inter individual variation in immune tolerance induction in patients with NAFLD, both in the presence and absence of cirrhosis

Persistent sulfate formation from London Fog to Chinese haze

Sulfate aerosols exert profound impacts on human and ecosystem health, weather, and climate, but their formation mechanism remains uncertain. Atmospheric models consistently underpredict sulfate levels under diverse environmental conditions. From atmospheric measurements in two Chinese megacities and complementary laboratory experiments, we show that the aqueous oxidation of SO2 by NO2 is key to efficient sulfate formation but is only feasible under two atmospheric conditions: on fine aerosols with high relative humidity and NH3 neutralization or under cloud conditions. Under polluted environments, this SO2 oxidation process leads to large sulfate production rates and promotes formation of nitrate and organic matter on aqueous particles, exacerbating severe haze development. Effective haze mitigation is achievable by intervening in the sulfate formation process with enforced NH3 and NO2 control measures. In addition to explaining the polluted episodes currently occurring in China and during the 1952 London Fog, this sulfate production mechanism is widespread, and our results suggest a way to tackle this growing problem in China and much of the developing world

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?

Obesity and non-alcoholic fatty liver disease (NAFLD) are contributing to the global rise in deaths from hepatocellular carcinoma (HCC). The pathogenesis of NAFLD-HCC is not well understood. The severity of hepatic steatosis, steatohepatitis and fibrosis are key pathogenic mechanisms, but animal studies suggest altered immune responses are also involved. Genetic studies have so far highlighted a major role of gene variants promoting fat deposition in the liver (PNPLA3 rs738409; TM6SF2 rs58542926). Here, we have considered single-nucleotide polymorphisms (SNPs) in candidate immunoregulatory genes (MICA rs2596542; CD44 rs187115; PDCD1 rs7421861 and rs10204525), in 594 patients with NAFLD and 391 with NAFLD-HCC, from three European centres. Associations between age, body mass index, diabetes, cirrhosis and SNPs with HCC development were explored. PNPLA3 and TM6SF2 SNPs were associated with both progression to cirrhosis and NAFLD-HCC development, while PDCD1 SNPs were specifically associated with NAFLD-HCC risk, regardless of cirrhosis. PDCD1 rs7421861 was independently associated with NAFLD-HCC development, while PDCD1 rs10204525 acquired significance after adjusting for other risks, being most notable in the smaller numbers of women with NAFLD-HCC. The study highlights the potential impact of inter individual variation in immune tolerance induction in patients with NAFLD, both in the presence and absence of cirrhosis

CODE ME A GOOD REASON: JOSEPH WEIZENBAUM AND A RHETORIC OF ETHICAL AI

Joseph Weizenbaum was a Massachusetts Institute of Technology professor often credited with creating the first chatbot, or automated computer conversationalist, in 1966. He named it ELIZA. Ten years later, however, he wrote Computer Power and Human Reason: From Judgment to Calculation, a book questioning the ethics of natural language processing, AI, and instrumental reason. This dissertation presents Weizenbaum as an early 20th century rhetorical theorist of computation. With an understanding of rhetoric as the material means for generating good reasons for living together, I articulate how Weizenbaum’s rhetorical interventions around the early development of computational culture can inform the ethics of engineering broadly and the development of AI specifically. The first chapter provides an overview of my historical and theoretical framework. The second chapter starts with Weizenbaum’s childhood and ends with the release of ELIZA. The third chapter chronicles his growing disillusionment with computers in society in the context of the Vietnam War. The final two chapters are dedicated to the book and reactions from a prominent figure in the history of AI, John McCarthy. Informed by Weizenbaum, I recuperate rhetoric as a practice of reason composed of technē that requires phronêsis in order to be realized in its full ethical potential. I argue that recognizing the practice of rhetoric inherent in engineering and ethics can better equip engineers and the public to manage scientific and technological uncertainty with the care necessary for a humane future

THE PROMISES, PROBLEMS, AND POSSIBILITIES FOR ALT-NETWORKS

The Promises, Problems, and Possibilities for Alt-Networks Introduction Social media has become a central facet of contemporary life and that centralization has narrowed our perspectives and lessened our possibilities (Pariser, 2011; Vaidhyanathan, 2018). This centralizing of social media networks happens for their individual users, but also at the level of how social media informs our discourses through journalistic practice, government institutions, industry sectors. Because of the role that social media now play, we have become acutely aware of their shortcomings. Their platforms not only host but actively cultivate toxic and abusive environments for many of its users. In addition to their functions of interaction, they also provide avenues for increasing governmental control through surveillance or gatekeeping. Given the lack of adequate response from tech companies to these long standing issues, it was inevitable that something had to happen. In response to these conditions, tech advocates, activists, students, and scholars have launched numerous alternatives to mainstream social networks. These networks rethink what social media can and should do in times of over reliance on monolithic digital platforms. Some networks redesign the user’s experience to lessen or eliminate harassment; some networks focus on data privacy responsibilities; some create spaces where non-centralized networks can persist even against oppressive governmental regimes. Given the rise and differentiation of alt-networks, there is a need to study and examine the proliferation of alt-networks. This panel offers four presentations varied in objects, different in methodological approaches, and diverse in their claims. In examining alt-networks, this panel will explore how these redesigned digital platforms respond to demands of scalability, how political activists develop and deploy alt-networks for protests, how researchers could cultivate a games theory approach to studying alt-networks and, finally, how the lack of certain features in alt-networks may doom their survival. The methods being explored will include critical theory, social science research, methodological discussion, and critical analysis through a rhetorical lens. Ultimately, our panel hopes to join in on emerging conversations about the ecology of networks and contribute valuable insights for internet research. A Network of Alt-Networks These papers have been carefully assembled to represent a substantial spectrum of the promises, problems, and possibilities for Alt-Tech today. In the first presentation, the paper develops a games theory approach to studying alt-networks, in this case, Mastodon instances. This is an important development as mainstream social media networks have benefited from years of research approaches, new networked objects create new networked questions requiring new methodological considerations. Related to this problem, the second presentation examines how and when alt-networks engage or resist the inevitable need to scale their operations. Such a study is important because mainstream social media impose a will to scale in ways that make it seem natural and unstoppable. The third presentation engages activists and how ad hoc alt-networks allow for platforms that avoid and leverage themselves against oppressive regimes. Finally, the fourth presentation will explore why alt-networks have so far failed alt-right political actors. This argument will look at how micro-interactions on platforms inform and drive a dangerous cycle of political antagonism. As a set, these presentations will give AoIR attendees a comprehensive survey of sites, methods, and sources for engaging and analyzing alt-networks. While the papers all draw heavily on critical theory and analysis, each differs in how they approach their objects of analysis. Using technical approaches, social science methods, speculative means, and rhetorical analysis the papers also demonstrate a wide swath of ways to encounter the alt-network. Finally, the sourcing and discourse engaged by each presentation activates multiple academic discussions while also sticking close to shared themes and concerns. The Possibilities of Alt-Networks This panel builds on recent work concerning the disappointment with mainstream social networks but also the promise of alternatives (Gehl, 2015, Tufekci, 2017). The adherence to tech industry’s unfair labor practices, the inability to respond to users’ needs, the lack of clear and consistent privacy responsibilities, the weak submission to governmental control— these concerns with social media have all been written (Noble, 2018; Roberts, 2019). The rise and proliferation of Alt-Networks is an important development for internet researchers because those innovations rekindle the earliest aims of the internet itself. Namely, the construction of a system whose topological configurations resisted centralization and allowed for its users to develop multiple ways of communicating knowledge to one another